After a tragic accident, one of Joan's oldest friends is rushed to Minneapolis to be treated by her, forcing Amy to confront her about her illness. Richard and TJ find themselves at odds when they treat a tech bro who thrives on pushing boundaries. Michael tries to pick up the pieces in the wake of his fractured marriage.
An outdated medical proxy form creates tension between a patient's ex-husband and current partner. Amy, Jake, and new intern Hannah investigate a college student's sudden blindness.
Amy and Gina, with an assist from Jake, team up to help a victim of domestic abuse, while TJ finds himself in the spotlight when he, Sonya and Liz treat a social media influencer.
Jake refuses to give up on a beloved patient, landing himself in conflict with several Westside surgeons and when Amy's neuro tests elicit memories of Danny, she pushes herself too far.
Grief helps clarify Jake's feelings for Amy, and a flashback to the pandemic reveals the truth about why he stayed at Westside. To Hannah's surprise and dismay, Charlie goes too far with their plan to destroy Amy, causing explosive repercussions.
With the search underway to find out the truth about Amy's hacked accounts, she and Sonya butt heads while treating a homeless patient with a crush injury who was dumped in front of Westside Hospital. Jake and TJ help a distraught mother figure out why her daughter is in a coma. Hannah cares for a charming high school athlete, while working with Charlie to cover their tracks by infiltrating the hospital computer system. Unfortunately, those efforts result in major collateral damage.
The search for Amy's hacker intensifies when the hospital finally brings in the FBI. Hannah, devastated by the death of her patient, works with Amy to treat a sick older man whose daughter believes has been poisoned. Meanwhile, Sonya and TJ examine middle school kids for scoliosis, and discover a child with a different ailment and a home situation that may have caused it to get much worse.
Uma reviravolta chocante acontece quando Amy e Jake tratam uma gestante ferida durante um assalto. Michael se vê desafiado a se abrir quando a terapeuta de Katie o convida, junto com Amy, para uma sessão. TJ e Sonya ajudam Julie a lidar com uma doença misteriosa e um romance inesperado.
Enquanto lida com as consequências do segredo de Katie, Amy trata uma paciente em estado crítico que também guarda um segredo sombrio. Gina e Jake avaliam um jogador de pôquer de nível mundial. Sonya e TJ investigam a teoria por trás das frequentes ausências de Joan, e Richard retorna com uma carta na manga.
Met with hostility upon his return, Richard looks to redeem himself while treating an overworked food delivery worker. Sonya and TJ enlist Jake's help with the delicate Joan situation. Amy and TJ take on the case of a well-known medical malpractice lawyer, leading to unexpected complications.
After a tragic accident, one of Joan's oldest friends is rushed to Minneapolis to be treated by her, forcing Amy to confront her about her illness. Richard and TJ find themselves at odds when they treat a tech bro who thrives on pushing boundaries. Michael tries to pick up the pieces in the wake of his fractured marriage.
When Amy and Michael take Katie on a road trip to her college orientation, they pass a familiar campsite and decide to stop and hike the trail. The journey quickly becomes harrowing when they discover an injured man whose life hangs in the balance. Stranded in the middle of nowhere, with no cell service, it's up to the three of them to somehow save him.
On her last day at Westside, Joan chooses an unlikely successor, crowns a Chief Resident and imparts some final wisdom to the next generation. Gina steps in to help TJ's patient, a foster child suffering from rheumatoid arthritis. Amy and Jake's tension intensifies while treating a pregnant teen caught between her divorced parents.
On Michael's first day as Chief of Internal Medicine, Joan arrives at the hospital as a patient in dire straits. Amy, determined to save her, clashes repeatedly with Richard over Joan's treatment plan. Meanwhile, Gina makes a nearly impossible medical decision for a young patient and Liz fights for her allegations against Richard to be taken seriously.
In an effort to save a crashing Richard from a deadly virus, Amy gets infected with it. Michael and the team work tirelessly to help her and the other patients, but their experimental treatments fail, and Amy becomes critically ill.
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