E.R. trata do cotidiano da emergência de um hospital público de Chicago, visto sob a ótica dos médicos e enfermeiros que ali trabalham. Os conflitos profissionais e as histórias dos pacientes atendidos no pronto-socorro misturam-se aos dramas pessoais dos médicos.
Cynthia Hooper starts as the new desk clerk. Benton and Carla disagree over whether or not their son should be circumcised. Al gets in an accident at work.
Mark treats an old lady who has been brutally raped. Carter's grandmother visits Carol's clinic. After he's touched by Benton, a blind man can see again!
Kerry starts to doubt the methods of Synergix. Carter tries to help his cousin beat his drug addiction. Jeanie becomes Scott Anspaugh's part-time caregiver.
Greene flies to San Diego when his mother falls and is hospitalized. His concern increases when he finds her acting "completely loony and out of control." To make matters worse, he butts heads with his dad over her care.
Mark finds out Cynthia has moved. Carter's cousin Chase is brought in because of a heroin overdose. Doug and Kerry clash after she found a flaw in his study.
Jeanie fears Scott Anspaugh's cancer may have returned. Hathaway learns a disturbing secret about a 16-year-old girl. A pregnant patient fears she'll miscarry; Morgenstern returns to work, but perhaps too soon after his heart attack.
Carter finally works up enough nerve to ask Del Amico out. Jeanie tries to help Scotty decide whether to undergo an experimental treatment and Benton takes unexpected action during an operation with Morgenstern.
Del Amico, Ross and Corday confront disturbing situations after the bombing of a women's clinic. Benton comes under review for controversial actions in the OR. Jeanie endures one of the most difficult days of her life as she says goodbye to a friend.
A 31-year-old security guard is brought in suffering from severe chemical burns, and a 21-year-old man is wheeled in after falling 75 feet into a river. Meanwhile, Benton is upset that Carla's boyfriend is part of Reese's baptism.
Ross treats a 6-month-old recovering from methadone withdrawal. A televangelist and his wife, who's suffering from an infection, plan a broadcast from the ER. Del Amico's old boyfriend arrives, and Jeanie fears her health is rapidly declining.
Ross and Hathaway's jobs are in jeopardy after their unauthorized treatment of a drug-addicted 7-month-old boy is discovered. Corday loses her sponsorship. Carter suspects Del Amico's boyfriend when drugs are stolen.
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